ea0077p135 | Adrenal and Cardiovascular | SFEBES2021
Halsall David
, Wiegard Martin
, Goudie Robert
, Taylor Kevin
, Cowan Sarah
, Prellor Jacobus
, Gurnell Mark
Background: SARS-CoV-2 targets membrane-bound angiotensin-converting enzyme 2 (ACE2) to achieve cellular entry. Resultant loss of ACE2 function may lead to unregulated activation of the renin-angiotensin-aldosterone system (RAAS), contributing to the pathogenesis of hypertension and triggering a proinflammatory cascade. However, evidence to support this is conflicting, with either no change or an increase in the concentration of circulating aldosterone reported in patients wit...